New Research on Targeted Protein for Pain Relief

Researchers find a way to isolate key protein that can relieve chronic pain and other conditions

Credit: Felix Hausch

Many issues including chronic pain, depression and obesity are linked to a key protein called  “FK506-binding protein 51,” or FKBP51. Historically this protein has been difficult to isolate without affecting other proteins in the body. 

“Now a research group has developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood.”

The results of this research were presented at the American Chemical Society (ACS) Spring 2019 National Meeting & Exposition. By developing this highly selective protein inhibitor: SAFit2, the researchers claim it could be a therapeutic option to treat conditions like chronic pain, as well as many others.  In 3 mouse model tests, the introduction of SAFit2 was found to ameliorate inflammatory pain-induced disabilities, and diet-induced obesity, as well as positively affect stress-coping behaviors.

Read the full article here.